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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 1
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1994 2
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1998 1
2000 1
2001 2
2002 3
2003 1
2004 1
2005 1
2007 1
2008 1
2009 3
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2013 1
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38 results

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Page 1
CSN6 Promotes the Migration and Invasion of Cervical Cancer Cells by Inhibiting Autophagic Degradation of Cathepsin L.
Mao Z, Sang MM, Chen C, Zhu WT, Gong YS, Pei DS. Mao Z, et al. Int J Biol Sci. 2019 May 12;15(6):1310-1324. doi: 10.7150/ijbs.32987. eCollection 2019. Int J Biol Sci. 2019. PMID: 31223289 Free PMC article.
However, the detailed biological functions of CSN6 on CTSL in CC metastasis have not been well clarified. Our data has shown that CSN6 and CTSL are positively correlated. The overexpression of CSN6 and CTSL might be a strong indicator for CC enhanced aggressi …
However, the detailed biological functions of CSN6 on CTSL in CC metastasis have not been well clarified. Our data has shown that CSN …
A combined treatment with melatonin and andrographis promotes autophagy and anticancer activity in colorectal cancer.
Zhao Y, Wang C, Goel A. Zhao Y, et al. Carcinogenesis. 2022 Apr 25;43(3):217-230. doi: 10.1093/carcin/bgac008. Carcinogenesis. 2022. PMID: 35089340 Free PMC article.
RNA-sequencing analysis revealed candidate pathways and genes that mediated antitumor efficacy of MLT and Andro in CRC, among which autophagy pathway and related genes, including NR4A1, CTSL and Atg12, were found to be primarily responsible for the increased anticancer eff …
RNA-sequencing analysis revealed candidate pathways and genes that mediated antitumor efficacy of MLT and Andro in CRC, among which autophag …
Stress-resistant Translation of Cathepsin L mRNA in Breast Cancer Progression.
Tholen M, Wolanski J, Stolze B, Chiabudini M, Gajda M, Bronsert P, Stickeler E, Rospert S, Reinheckel T. Tholen M, et al. J Biol Chem. 2015 Jun 19;290(25):15758-15769. doi: 10.1074/jbc.M114.624353. Epub 2015 May 8. J Biol Chem. 2015. PMID: 25957406 Free PMC article.
This goes along with increased CTSL activity in various tumor entities; however, the mechanisms leading to high CTSL levels are incompletely understood. With the help of the polyoma middle T oncogene driven breast cancer mouse model expressing a human CTSL ge …
This goes along with increased CTSL activity in various tumor entities; however, the mechanisms leading to high CTSL levels ar …
Targeting Cathepsin L in Cancer Management: Leveraging Machine Learning, Structure-Based Virtual Screening, and Molecular Dynamics Studies.
Almalki AA, Shafie A, Hazazi A, Banjer HJ, Bakhuraysah MM, Almaghrabi SA, Alsaiari AA, Alsaeedi FA, Ashour AA, Alharthi A, Alharthi NS, Anjum F. Almalki AA, et al. Int J Mol Sci. 2023 Dec 7;24(24):17208. doi: 10.3390/ijms242417208. Int J Mol Sci. 2023. PMID: 38139037 Free PMC article.
Currently, no natural CTSL inhibitors are approved for clinical use. Consequently, the development of novel CTSL inhibition strategies is an urgent necessity. ...ZINC4097985 and ZINC4098355 can be considered promising candidates for CTSL inhibition after e …
Currently, no natural CTSL inhibitors are approved for clinical use. Consequently, the development of novel CTSL inhibition st …
Overexpression of cysteine cathepsin L is a marker of invasion and metastasis in ovarian cancer.
Zhang W, Wang S, Wang Q, Yang Z, Pan Z, Li L. Zhang W, et al. Oncol Rep. 2014 Mar;31(3):1334-42. doi: 10.3892/or.2014.2967. Epub 2014 Jan 8. Oncol Rep. 2014. PMID: 24402045
In particular, CTSL was related to lymph node metastasis, CC was related to liver metastasis and omental metastasis, and CTSB and CTSL expression levels were found to be independent prognostic factors in ovarian cancer. ...Taken together, we demonstrated that the ov …
In particular, CTSL was related to lymph node metastasis, CC was related to liver metastasis and omental metastasis, and CTSB and …
Chinese herb cinobufagin-reduced cancer pain is associated with increased peripheral opioids by invaded CD3/4/8 lymphocytes.
Chen T, Yuan S, Wan XN, Zhan L, Yu XQ, Zeng JH, Li H, Zhang W, Hu XY, Ye YF, Hu W. Chen T, et al. Oncotarget. 2017 Feb 14;8(7):11425-11441. doi: 10.18632/oncotarget.14005. Oncotarget. 2017. PMID: 28002791 Free PMC article.
RT-PCR was conducted to determine the gene expression of POMC and Cathepsin L (CTSL). Chemotaxis was examined using a transwell-based migration assay. ...Cinobufagin also largely increased the proliferation of immune cells and inhibited H22 hepatoma carcinoma cell prolifer …
RT-PCR was conducted to determine the gene expression of POMC and Cathepsin L (CTSL). Chemotaxis was examined using a transwell-based …
[The lysosomal cathepsins B, L and D in development of murine experimental leukemias].
Khalikova TA, Korolenko TA, Il'nitskaia SI. Khalikova TA, et al. Biomed Khim. 2009 Sep-Oct;55(5):621-34. Biomed Khim. 2009. PMID: 20017393 Russian.
The present study was designed to investigate activity of cathepsins B, L and D activity in the development and treatment of murine experimental leukemias and to determine the correlation of these proteases with tumor malignancy and the chemotherapy effect. ...These data h …
The present study was designed to investigate activity of cathepsins B, L and D activity in the development and treatment of murine exper …
Selective cancer targeting with prodrugs activated by histone deacetylases and a tumour-associated protease.
Ueki N, Lee S, Sampson NS, Hayman MJ. Ueki N, et al. Nat Commun. 2013;4:2735. doi: 10.1038/ncomms3735. Nat Commun. 2013. PMID: 24193185 Free article.
By coupling an acetylated lysine group to puromycin, a masked cytotoxic agent is created, which is serially activated by HDAC and an endogenous protease cathepsin L (CTSL) that remove the acetyl group first and then the unacetylated lysine group liberating puromycin. The a …
By coupling an acetylated lysine group to puromycin, a masked cytotoxic agent is created, which is serially activated by HDAC and an endogen …
Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer.
Herszényi L, Farinati F, Cardin R, István G, Molnár LD, Hritz I, De Paoli M, Plebani M, Tulassay Z. Herszényi L, et al. BMC Cancer. 2008 Jul 10;8:194. doi: 10.1186/1471-2407-8-194. BMC Cancer. 2008. PMID: 18616803 Free PMC article.
The tumor marker utility and prognostic relevance of these proteases have not been evaluated in the same experimental setting and compared with that of CEA and CA-19-9. METHODS: Protease, CEA and CA 19-9 serum or plasma levels were determined in 56 patients with colorectal …
The tumor marker utility and prognostic relevance of these proteases have not been evaluated in the same experimental setting and com …
38 results